Folate

Deficiency in folate can lead to nutritional and macrocytic anaemias. Diets lacking in raw fruits, vegetables, or other foods high in folic acid can cause this deficit; this can be the case for those who are chronic alcoholics, drug addicts, old, from low-income backgrounds, etc. Furthermore, neural tube abnormalities in the foetus have been linked to low serum folate levels during pregnancy. 1 The two main causes of folate insufficiency in humans are malabsorption and dietary deficiencies. 2. Red blood cell regeneration, DNA synthesis, and proper metabolism all depend on folate. Megaloblastic anaemia can result from untreated deficiencies. To accurately evaluate the aetiology of anaemia, it is recommended to measure the concentration of both vitamin B12 and folate because deficiencies in any of these nutrients might result in megaloblastic anaemia.